| 1. Jornada | 16.03.2021 | Almagro | - | Tristan Suárez | 1:3 | ||||
| 2. Jornada | 20.03.2021 | Gimnasia de Jujuy | - | Almagro | 1:2 | ||||
| 5. Jornada | 11.04.2021 | Almagro | - | Independiente Rivadavia | 0:2 | ||||
| 6. Jornada | 18.04.2021 | Atlético Rafaela | - | Almagro | 4:1 |  |
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| 8. Jornada | 30.04.2021 | Brown de Adrogué | - | Almagro | 2:0 | ||||
| 9. Jornada | 09.05.2021 | Almagro | - | San Martín de San Juan | 0:1 | ||||
| 12. Jornada | 17.06.2021 | Defensores de Belgrano | - | Almagro | 1:0 | ||||
| 13. Jornada | 22.06.2021 | Almagro | - | Ramón Santamarina | 1:1 | ||||
| 14. Jornada | 27.06.2021 | Almagro | - | All Boys | 3:0 | ||||
| 18. Jornada | 24.07.2021 | Tristan Suárez | - | Almagro | 1:1 | ||||
| 24. Jornada | 04.09.2021 | Guillermo Brown | - | Almagro | 1:0 | ||||
| 28. Jornada | 01.10.2021 | San Telmo | - | Almagro | 2:1 | ||||
| 34. Jornada | 15.11.2021 | Almagro | - | Ferro Carril Oeste | 2:3 |  |
Argentina