2. Jornada | 11.08.2021 | Marathón | - | Lobos UPNFM | 5:1 | ||||
9. Jornada | 15.09.2021 | Lobos UPNFM | - | Real Sociedad | 2:0 | ||||
10. Jornada | 20.09.2021 | Lobos UPNFM | - | Motagua | 2:2 | ||||
11. Jornada | 27.09.2021 | Platense | - | Lobos UPNFM | 2:3 | ||||
13. Jornada | 10.10.2021 | Lobos UPNFM | - | Vida | 0:0 | ||||
14. Jornada | 17.10.2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 | ||||
15. Jornada | 25.10.2021 | Lobos UPNFM | - | Real España | 1:2 | ||||
17. Jornada | 31.10.2021 | Olimpia | - | Lobos UPNFM | 2:1 |