| 1. Jornada | 06.01.2022 | Atlético San Luis [Sub 20] | - | CF Pachuca [Sub 20] | 0:2 |  |
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| 3. Jornada | 20.01.2022 | Atlético San Luis [Sub 20] | - | FC Juárez [Sub 20] | 7:1 | ||||
| 5. Jornada | 12.02.2022 | Atlético San Luis [Sub 20] | - | Deportivo Toluca [Sub 20] | 4:1 | |
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| 7. Jornada | 26.02.2022 | CF Monterrey [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 | ||||
| 10. Jornada | 13.03.2022 | Atlético San Luis [Sub 20] | - | Puebla FC [Sub 20] | 3:1 | ||||
| 11. Jornada | 17.03.2022 | Gallos Blancos [Sub 20] | - | Atlético San Luis [Sub 20] | 3:0 | ||||
| 12. Jornada | 01.04.2022 | Atlético San Luis [Sub 20] | - | Mazatlán FC [Sub 20] | 1:2 | ||||
| 9. Jornada | 06.04.2022 | Club Tijuana [Sub 20] | - | Atlético San Luis [Sub 20] | 2:1 | ||||
| 13. Jornada | 09.04.2022 | Atlético San Luis [Sub 20] | - | Club León [Sub 20] | 1:1 | ||||
| 14. Jornada | 15.04.2022 | Club Necaxa [Sub 20] | - | Atlético San Luis [Sub 20] | 3:0 | |
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| 15. Jornada | 20.04.2022 | Atlético San Luis [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | |
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| 16. Jornada | 24.04.2022 | Cruz Azul [Sub 20] | - | Atlético San Luis [Sub 20] | 2:2 |  |
México