| 2. Jornada | 01.08.2021 | Santos Laguna [Sub 18] | - | Cruz Azul [Sub 18] | 1:2 | ||||
| 3. Jornada | 06.08.2021 | Club Necaxa [Sub 18] | - | Cruz Azul [Sub 18] | 5:0 | ||||
| 10. Jornada | 24.09.2021 | Puebla FC [Sub 18] | - | Cruz Azul [Sub 18] | 2:1 | ||||
| 12. Jornada | 03.10.2021 | Club Tijuana [Sub 18] | - | Cruz Azul [Sub 18] | 3:2 | ||||
| 17. Jornada | 07.11.2021 | Pumas UNAM [Sub 18] | - | Cruz Azul [Sub 18] | 2:2 |
México