| 2. Jornada | 02.08.2021 | Atlético San Luis [Sub 20] | - | Gallos Blancos [Sub 20] | 0:2 | ||||
| 3. Jornada | 08.08.2021 | Pumas UNAM [Sub 20] | - | Atlético San Luis [Sub 20] | 5:3 | ||||
| 4. Jornada | 12.08.2021 | Atlético San Luis [Sub 20] | - | Club Necaxa [Sub 20] | 1:2 | ||||
| 8. Jornada | 10.09.2021 | Puebla FC [Sub 20] | - | Atlético San Luis [Sub 20] | 2:2 | ||||
| 16. Jornada | 31.10.2021 | Atlético San Luis [Sub 20] | - | CF Monterrey [Sub 20] | 3:1 |
México