| 20. Jornada | 04.02.2022 | Neuchâtel Xamax FCS | - | FC Schaffhausen | 2:1 | ||||
| 21. Jornada | 11.02.2022 | FC Schaffhausen | - | FC Vaduz | 4:2 | ||||
| 22. Jornada | 19.02.2022 | FC Wil 1900 | - | FC Schaffhausen | 3:2 | ||||
| 19. Jornada | 22.02.2022 | FC Schaffhausen | - | FC Thun | 1:0 |  |
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| 23. Jornada | 25.02.2022 | FC Schaffhausen | - | FC Winterthur | 3:2 | ||||
| 24. Jornada | 01.03.2022 | FC Schaffhausen | - | Stade Lausanne-Ouchy | 0:1 | |
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| 26. Jornada | 11.03.2022 | FC Schaffhausen | - | Yverdon Sport FC | 3:1 | ||||
| 27. Jornada | 19.03.2022 | SC Kriens | - | FC Schaffhausen | 0:0 | ||||
| 28. Jornada | 01.04.2022 | FC Schaffhausen | - | Neuchâtel Xamax FCS | 2:1 | ||||
| 29. Jornada | 10.04.2022 | FC Vaduz | - | FC Schaffhausen | 2:3 | ||||
| 30. Jornada | 18.04.2022 | Yverdon Sport FC | - | FC Schaffhausen | 0:1 | ||||
| 31. Jornada | 22.04.2022 | FC Schaffhausen | - | FC Wil 1900 | 5:2 | ||||
| 32. Jornada | 29.04.2022 | FC Winterthur | - | FC Schaffhausen | 1:1 | ||||
| 33. Jornada | 06.05.2022 | FC Schaffhausen | - | SC Kriens | 4:1 | ||||
| 34. Jornada | 10.05.2022 | FC Thun | - | FC Schaffhausen | 2:5 | ||||
| 35. Jornada | 14.05.2022 | FC Schaffhausen | - | FC Aarau | 0:1 | ||||
| 36. Jornada | 21.05.2022 | Stade Lausanne-Ouchy | - | FC Schaffhausen | 1:2 |
Austria