| 1. Jornada | 23.07.2021 | FK Lviv | - | FK Mariupol | 1:1 | ||||
| 2. Jornada | 01.08.2021 | FK Mariupol | - | Desna Chernigov | 1:2 | ||||
| 7. Jornada | 12.09.2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 |  |
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| 9. Jornada | 25.09.2021 | FK Oleksandriya | - | FK Mariupol | 2:1 | |
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| 10. Jornada | 01.10.2021 | FK Mariupol | - | Rukh Lviv | 0:2 | ||||
| 11. Jornada | 16.10.2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | ||||
| 12. Jornada | 23.10.2021 | NK Veres | - | FK Mariupol | 2:0 | ||||
| 13. Jornada | 30.10.2021 | FK Mariupol | - | Dinamo Kiev | 2:3 | ||||
| 15. Jornada | 21.11.2021 | Vorskla Poltava | - | FK Mariupol | 5:1 | ||||
| 16. Jornada | 26.11.2021 | FK Mariupol | - | FK Lviv | 0:1 | |
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| 17. Jornada | 05.12.2021 | Desna Chernigov | - | FK Mariupol | 3:3 | |
Ucrania