| 1. Jornada | 25.07.2021 | Zorya Lugansk | - | FK Oleksandriya | 0:1 | ||||
| 2. Jornada | 02.08.2021 | Inhulets Petrove | - | Zorya Lugansk | 1:5 | ||||
| 5. Jornada | 22.08.2021 | FK Mariupol | - | Zorya Lugansk | 3:4 |  |
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| 8. Jornada | 19.09.2021 | Zorya Lugansk | - | Chernomorets Odessa | 3:0 | ||||
| 9. Jornada | 26.09.2021 | SK Dnipro-1 | - | Zorya Lugansk | 0:4 | ||||
| 10. Jornada | 03.10.2021 | Zorya Lugansk | - | Desna Chernigov | 2:0 | ||||
| 11. Jornada | 15.10.2021 | Shakhtar Donetsk | - | Zorya Lugansk | 6:1 | ||||
| 12. Jornada | 24.10.2021 | Zorya Lugansk | - | Kolos Kovalivka | 1:0 | ||||
| 14. Jornada | 07.11.2021 | Zorya Lugansk | - | NK Veres | 3:0 | ||||
| 15. Jornada | 20.11.2021 | FK Lviv | - | Zorya Lugansk | 2:1 |  |
Ucrania