| Eliminatoria previa | 18.03.2021 | Guaireña FC | - | River Plate | 1:2 | ||||
| Eliminatoria previa | 09.04.2021 | River Plate | - | Guaireña FC | 4:2 |  |
 |
||
| Grupo E | 23.04.2021 | River Plate | - | Corinthians SP | 0:0 | |
|||
| Grupo E | 30.04.2021 | Sport Huancayo | - | River Plate | 1:2 | |
|||
| Grupo E | 07.05.2021 | Peñarol | - | River Plate | 3:0 | ||||
| Grupo E | 14.05.2021 | River Plate | - | Sport Huancayo | 2:1 | |
|||
| Grupo E | 19.05.2021 | River Plate | - | Peñarol | 2:1 | |
Paraguay