| 1. Jornada | 09.08.2021 | FC Utrecht (J) | - | MVV | 0:1 | ||||
| 2. Jornada | 13.08.2021 | MVV | - | De Graafschap | 1:3 | ||||
| 3. Jornada | 20.08.2021 | MVV | - | Helmond Sport | 3:2 | ||||
| 6. Jornada | 10.09.2021 | FC Emmen | - | MVV | 7:1 | ||||
| 8. Jornada | 27.09.2021 | Jong Ajax | - | MVV | 3:1 | ||||
| 9. Jornada | 01.10.2021 | MVV | - | ADO Den Haag | 2:6 | ||||
| 10. Jornada | 09.10.2021 | VVV-Venlo | - | MVV | 2:0 | ||||
| 14. Jornada | 05.11.2021 | AZ Alkmaar (J) | - | MVV | 0:1 | ||||
| 15. Jornada | 15.11.2021 | MVV | - | FC Den Bosch | 0:1 | ||||
| 16. Jornada | 19.11.2021 | Almere City FC | - | MVV | 0:2 | ||||
| 17. Jornada | 26.11.2021 | MVV | - | Jong PSV | 1:2 | ||||
| 18. Jornada | 03.12.2021 | MVV | - | TOP Oss | 1:1 | ||||
| 19. Jornada | 10.12.2021 | SBV Excelsior | - | MVV | 2:1 | ||||
| 20. Jornada | 17.12.2021 | MVV | - | FC Emmen | 0:1 | ||||
| 21. Jornada | 07.01.2022 | Roda JC Kerkrade | - | MVV | 1:0 | ||||
| 28. Jornada | 25.02.2022 | FC Dordrecht | - | MVV | 3:1 | ||||
| 31. Jornada | 18.03.2022 | De Graafschap | - | MVV | 1:3 | ||||
| 32. Jornada | 27.03.2022 | MVV | - | Almere City FC | 0:3 | ||||
| 35. Jornada | 15.04.2022 | MVV | - | SBV Excelsior | 1:1 |
Bélgica