| 1. Jornada | 16.07.2022 | Tacuary | - | Guaireña FC | 0:0 | ||||
| 2. Jornada | 21.07.2022 | Tacuary | - | Cerro Porteño | 0:1 | ||||
| 3. Jornada | 23.07.2022 | Sportivo Ameliano | - | Tacuary | 2:0 | ||||
| 4. Jornada | 31.07.2022 | Tacuary | - | Club Olimpia | 2:1 |  |
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| 5. Jornada | 06.08.2022 | General Caballero DJLM | - | Tacuary | 0:4 | ||||
| 6. Jornada | 16.08.2022 | Tacuary | - | Resistencia SC | 1:1 | ||||
| 7. Jornada | 21.08.2022 | 12 de Octubre de Itauguá | - | Tacuary | 0:2 | ||||
| 8. Jornada | 29.08.2022 | Tacuary | - | Sol de América | 1:0 | ||||
| 9. Jornada | 04.09.2022 | Club Nacional | - | Tacuary | 1:0 | ||||
| 10. Jornada | 11.09.2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 11. Jornada | 14.09.2022 | Libertad | - | Tacuary | 2:0 | |
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| 12. Jornada | 19.09.2022 | Guaireña FC | - | Tacuary | 1:0 | ||||
| 13. Jornada | 26.09.2022 | Cerro Porteño | - | Tacuary | 5:0 | ||||
| 14. Jornada | 02.10.2022 | Tacuary | - | Sportivo Ameliano | 1:1 | |
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| 15. Jornada | 06.10.2022 | Club Olimpia | - | Tacuary | 1:0 | ||||
| 17. Jornada | 15.10.2022 | Resistencia SC | - | Tacuary | 0:3 | |
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| 18. Jornada | 22.10.2022 | Tacuary | - | 12 de Octubre de Itauguá | 5:1 | ||||
| 20. Jornada | 31.10.2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 21. Jornada | 06.11.2022 | Guaraní | - | Tacuary | 2:1 | |
Paraguay