| 3. Jornada | 16.02.2021 | Libertad | - | Cerro Porteño | 2:1 |  |
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| 4. Jornada | 22.02.2021 | Club Nacional | - | Libertad | 0:3 | ||||
| 8. Jornada | 14.03.2021 | Sol de América | - | Libertad | 0:2 | ||||
| 9. Jornada | 23.03.2021 | Libertad | - | Sportivo Luqueño | 2:0 | ||||
| 7. Jornada | 29.03.2021 | Libertad | - | Guaraní | 1:1 | ||||
| 10. Jornada | 04.04.2021 | Libertad | - | Club Olimpia | 0:1 | ||||
| 11. Jornada | 12.04.2021 | Libertad | - | Guaireña FC | 2:1 | |
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| 12. Jornada | 18.04.2021 | Cerro Porteño | - | Libertad | 0:3 | ||||
| 13. Jornada | 26.04.2021 | Libertad | - | Club Nacional | 1:1 | ||||
| 14. Jornada | 04.05.2021 | River Plate | - | Libertad | 1:3 | ||||
| 15. Jornada | 09.05.2021 | Libertad | - | 12 de Octubre de Itauguá | 3:1 | ||||
| 16. Jornada | 17.05.2021 | Guaraní | - | Libertad | 1:6 | ||||
| 17. Jornada | 22.05.2021 | Libertad | - | Sol de América | 1:2 |
Uruguay