| 2. Jornada | 05.02.2023 | Resistencia SC | - | Libertad | 0:2 | ||||
| 3. Jornada | 11.02.2023 | Libertad | - | Sportivo Luqueño | 1:1 | ||||
| 4. Jornada | 19.02.2023 | Club Nacional | - | Libertad | 1:2 | ||||
| 5. Jornada | 26.02.2023 | Libertad | - | Tacuary | 1:0 |  |
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| 6. Jornada | 06.03.2023 | Sportivo Trinidense | - | Libertad | 1:2 | ||||
| 7. Jornada | 11.03.2023 | Libertad | - | Guaireña FC | 2:0 | ||||
| 8. Jornada | 19.03.2023 | Club Olimpia | - | Libertad | 2:1 | ||||
| 9. Jornada | 31.03.2023 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 10. Jornada | 02.04.2023 | Libertad | - | Cerro Porteño | 5:0 | ||||
| 11. Jornada | 11.04.2023 | Sportivo Ameliano | - | Libertad | 2:5 | ||||
| 12. Jornada | 14.04.2023 | Guaraní | - | Libertad | 0:0 | ||||
| 13. Jornada | 18.04.2023 | Libertad | - | Resistencia SC | 4:0 | ||||
| 14. Jornada | 25.04.2023 | Sportivo Luqueño | - | Libertad | 0:2 | ||||
| 15. Jornada | 29.04.2023 | Libertad | - | Club Nacional | 2:1 | ||||
| 16. Jornada | 09.05.2023 | Tacuary | - | Libertad | 3:0 | ||||
| 17. Jornada | 13.05.2023 | Libertad | - | Sportivo Trinidense | 2:1 | ||||
| 18. Jornada | 17.05.2023 | Guaireña FC | - | Libertad | 0:2 | ||||
| 19. Jornada | 21.05.2023 | Libertad | - | Club Olimpia | 1:0 | ||||
| 20. Jornada | 28.05.2023 | General Caballero DJLM | - | Libertad | 0:2 |
Uruguay