| 1. Jornada | 23.01.2010 | Atenas | - | Defensor Sporting | 3:1 | ||||
| 2. Jornada | 31.01.2010 | Defensor Sporting | - | Danubio | 0:1 | ||||
| 3. Jornada | 06.02.2010 | Nacional | - | Defensor Sporting | 0:1 |  |
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| 4. Jornada | 13.02.2010 | Defensor Sporting | - | Central Español | 3:4 | ||||
| 5. Jornada | 21.02.2010 | Fénix | - | Defensor Sporting | 3:0 | ||||
| 6. Jornada | 27.02.2010 | Defensor Sporting | - | Rampla Juniors | 2:1 | ||||
| 8. Jornada | 13.03.2010 | Cerro Largo | - | Defensor Sporting | 1:3 | |
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| 10. Jornada | 28.03.2010 | Defensor Sporting | - | Peñarol | 2:3 | ||||
| 11. Jornada | 03.04.2010 | Racing | - | Defensor Sporting | 3:3 | ||||
| 12. Jornada | 09.04.2010 | Defensor Sporting | - | CA Cerro | 1:0 | ||||
| 13. Jornada | 17.04.2010 | Defensor Sporting | - | River Plate | 1:1 | ||||
| 14. Jornada | 25.04.2010 | Defensor Sporting | - | Montevideo Wanderers | 2:0 | ||||
| 15. Jornada | 02.05.2010 | Liverpool | - | Defensor Sporting | 3:0 |
Uruguay