| 1. Jornada | 29.08.2020 | Jong PSV | - | SBV Excelsior | 1:6 | ||||
| 3. Jornada | 11.09.2020 | AZ Alkmaar (J) | - | Jong PSV | 1:4 | ||||
| 2. Jornada | 14.09.2020 | Jong Ajax | - | Jong PSV | 1:2 | ||||
| 4. Jornada | 18.09.2020 | Jong PSV | - | FC Eindhoven | 1:2 | ||||
| 6. Jornada | 02.10.2020 | Jong PSV | - | Telstar | 3:0 | ||||
| 7. Jornada | 20.10.2020 | Jong PSV | - | NEC Nijmegen | 1:1 | ||||
| 13. Jornada | 20.11.2020 | MVV | - | Jong PSV | 3:3 | ||||
| 12. Jornada | 24.11.2020 | Jong PSV | - | FC Utrecht (J) | 1:1 | ||||
| 14. Jornada | 27.11.2020 | Helmond Sport | - | Jong PSV | 1:0 | ||||
| 10. Jornada | 30.11.2020 | Jong PSV | - | SC Cambuur | 0:1 | ||||
| 16. Jornada | 11.12.2020 | TOP Oss | - | Jong PSV | 3:2 | ||||
| 18. Jornada | 05.01.2021 | Jong PSV | - | Go Ahead Eagles | 2:3 | ||||
| 20. Jornada | 18.01.2021 | Jong PSV | - | NAC Breda | 1:1 | ||||
| 21. Jornada | 22.01.2021 | SC Cambuur | - | Jong PSV | 5:1 | ||||
| 22. Jornada | 29.01.2021 | Jong PSV | - | Jong Ajax | 1:2 | ||||
| 23. Jornada | 05.02.2021 | Roda JC Kerkrade | - | Jong PSV | 5:1 | ||||
| 24. Jornada | 23.02.2021 | Jong PSV | - | Helmond Sport | 2:2 | ||||
| 27. Jornada | 09.03.2021 | Jong PSV | - | FC Dordrecht | 0:1 | ||||
| 30. Jornada | 15.03.2021 | FC Utrecht (J) | - | Jong PSV | 1:6 | ||||
| 33. Jornada | 09.04.2021 | FC Eindhoven | - | Jong PSV | 0:2 |
Bélgica