| 9. Jornada | 04.03.2021 | Pumas UNAM [Sub 20] | - | Santos Laguna [Sub 20] | 0:0 | ||||
| 12. Jornada | 21.03.2021 | Santos Laguna [Sub 20] | - | Club León [Sub 20] | 3:0 | ||||
| 13. Jornada | 04.04.2021 | Deportivo Guadalajara [Sub 20] | - | Santos Laguna [Sub 20] | 5:2 | ||||
| 14. Jornada | 11.04.2021 | Gallos Blancos [Sub 20] | - | Santos Laguna [Sub 20] | 1:0 |
México