| 9. Jornada | 18.08.2022 | Cruz Azul | - | Club Tijuana | 1:2 | ||||
| 10. Jornada | 21.08.2022 | CF América | - | Cruz Azul | 7:0 | ||||
| 11. Jornada | 28.08.2022 | Cruz Azul | - | Gallos Blancos | 2:1 |  |
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| 12. Jornada | 03.09.2022 | FC Juárez | - | Cruz Azul | 2:2 |  |
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| 13. Jornada | 07.09.2022 | CF Monterrey | - | Cruz Azul | 3:2 | ||||
| 16. Jornada | 16.09.2022 | Cruz Azul | - | Club León | 2:1 | |
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| 15. Jornada | 19.09.2022 | Pumas UNAM | - | Cruz Azul | 1:2 | ||||
| 17. Jornada | 02.10.2022 | Cruz Azul | - | Deportivo Guadalajara | 2:1 | |
Ecuador
