| 1. Jornada | 14.08.2021 | Mosta FC | - | Birkirkara FC | 0:3 | ||||
| 3. Jornada | 11.09.2021 | Mosta FC | - | Hamrun Spartans | 1:2 | ||||
| 9. Jornada | 20.11.2021 | Mosta FC | - | Gżira United | 2:2 | ||||
| 10. Jornada | 27.11.2021 | Valletta FC | - | Mosta FC | 3:1 | ||||
| 11. Jornada | 04.12.2021 | Mosta FC | - | Gudja United | 0:3 | ||||
| 13. Jornada | 18.12.2021 | Mosta FC | - | Sirens FC | 2:3 | ||||
| 14. Jornada | 17.01.2022 | Hamrun Spartans | - | Mosta FC | 2:1 | ||||
| 15. Jornada | 22.01.2022 | Mosta FC | - | Hibernians FC | 1:1 | ||||
| 18. Jornada | 12.02.2022 | Floriana FC | - | Mosta FC | 2:0 | ||||
| 20. Jornada | 27.02.2022 | Gżira United | - | Mosta FC | 3:4 | ||||
| 21. Jornada | 05.03.2022 | Mosta FC | - | Valletta FC | 2:2 | ||||
| 22. Jornada | 12.03.2022 | Gudja United | - | Mosta FC | 1:0 |
Malta