| 5. Jornada | 29.08.2021 | Houston Dynamo | - | Minnesota United FC | 1:2 | ||||
| 6. Jornada | 04.09.2021 | Houston Dynamo | - | Portland Timbers | 0:2 | ||||
| 6. Jornada | 12.09.2021 | Houston Dynamo | - | Austin FC | 3:0 | ||||
| 6. Jornada | 16.09.2021 | Los Angeles Galaxy | - | Houston Dynamo | 1:1 | ||||
| 6. Jornada | 19.09.2021 | Houston Dynamo | - | FC Dallas | 3:2 | ||||
| 6. Jornada | 26.09.2021 | Minnesota United FC | - | Houston Dynamo | 2:0 | ||||
| 6. Jornada | 30.09.2021 | Houston Dynamo | - | Vancouver Whitecaps | 0:0 | ||||
| 7. Jornada | 03.10.2021 | Sporting Kansas City | - | Houston Dynamo | 4:2 | ||||
| 7. Jornada | 17.10.2021 | Houston Dynamo | - | Seattle Sounders | 2:1 | ||||
| 7. Jornada | 21.10.2021 | Houston Dynamo | - | Los Angeles Galaxy | 0:3 | ||||
| 7. Jornada | 31.10.2021 | Houston Dynamo | - | Colorado Rapids | 0:1 |
Estados Unidos