| 9. Jornada | 21.09.2008 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
| 10. Jornada | 28.09.2008 | Club San Luis | - | Puebla FC | 1:1 | ||||
| 11. Jornada | 05.10.2008 | Indios Juárez | - | Club San Luis | 2:3 | ||||
| 14. Jornada | 26.10.2008 | Club San Luis | - | CF Monterrey | 2:0 | ||||
| 15. Jornada | 02.11.2008 | Club Necaxa | - | Club San Luis | 1:1 | ||||
| 16. Jornada | 09.11.2008 | Club San Luis | - | Santos Laguna | 2:2 | ||||
| 17. Jornada | 16.11.2008 | Deportivo Toluca | - | Club San Luis | 1:0 |  |
Estados Unidos
México