| 1. Jornada | 13.08.2021 | Hamrun Spartans | - | Valletta FC | 1:2 | ||||
| 2. Jornada | 21.08.2021 | Valletta FC | - | Balzan FC | 1:0 | ||||
| 3. Jornada | 11.09.2021 | Floriana FC | - | Valletta FC | 3:0 | ||||
| 4. Jornada | 18.09.2021 | Valletta FC | - | Gżira United | 0:2 | ||||
| 5. Jornada | 25.09.2021 | Gudja United | - | Valletta FC | 2:0 | ||||
| 9. Jornada | 20.11.2021 | Sliema Wanderers | - | Valletta FC | 0:3 | ||||
| 13. Jornada | 19.12.2021 | Balzan FC | - | Valletta FC | 2:1 | ||||
| 14. Jornada | 17.01.2022 | Valletta FC | - | Floriana FC | 0:2 | ||||
| 15. Jornada | 23.01.2022 | Gżira United | - | Valletta FC | 1:1 | ||||
| 16. Jornada | 30.01.2022 | Valletta FC | - | Gudja United | 1:3 |  |
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| 19. Jornada | 20.02.2022 | St. Luċija FC | - | Valletta FC | 2:1 | ||||
| 20. Jornada | 26.02.2022 | Valletta FC | - | Sliema Wanderers | 1:0 |
Malta