| 2. Jornada | 11.02.2018 | Libertad | - | Guaraní | 2:0 |  |
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| 4. Jornada | 26.02.2018 | Club Olimpia | - | Guaraní | 5:2 | ||||
| 5. Jornada | 05.03.2018 | Guaraní | - | Independiente CG | 0:1 | ||||
| 6. Jornada | 11.03.2018 | General Díaz | - | Guaraní | 0:3 | |
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| 7. Jornada | 15.03.2018 | Guaraní | - | Sportivo Luqueño | 1:4 |  |
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| 12. Jornada | 17.04.2018 | Sol de América | - | Guaraní | 0:0 | ||||
| 16. Jornada | 08.05.2018 | Independiente CG | - | Guaraní | 2:1 | ||||
| 17. Jornada | 14.05.2018 | Guaraní | - | General Díaz | 2:2 | |
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| 19. Jornada | 26.05.2018 | Club Nacional | - | Guaraní | 3:0 | ||||
| 21. Jornada | 06.06.2018 | Cerro Porteño | - | Guaraní | 2:1 |  |
Paraguay