| 1. Jornada | 10.01.2021 | Atlas Guadalajara | - | CF Monterrey | 0:2 | ||||
| 2. Jornada | 17.01.2021 | CF Monterrey | - | CF América | 1:0 | ||||
| 4. Jornada | 03.02.2021 | Puebla FC | - | CF Monterrey | 0:0 |  |
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| 5. Jornada | 07.02.2021 | CF Monterrey | - | Pumas UNAM | 1:0 | ||||
| 6. Jornada | 15.02.2021 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
| 7. Jornada | 20.02.2021 | Club Necaxa | - | CF Monterrey | 1:1 | ||||
| 8. Jornada | 01.03.2021 | CF Monterrey | - | Club Tijuana | 1:1 | ||||
| 9. Jornada | 04.03.2021 | FC Juárez | - | CF Monterrey | 1:6 | ||||
| 10. Jornada | 07.03.2021 | CF Monterrey | - | Gallos Blancos | 2:1 | ||||
| 3. Jornada | 11.03.2021 | CF Monterrey | - | Club León | 1:1 | ||||
| 11. Jornada | 14.03.2021 | Cruz Azul | - | CF Monterrey | 1:0 | ||||
| 16. Jornada | 25.04.2021 | UANL Tigres | - | CF Monterrey | 2:1 | ||||
| 17. Jornada | 02.05.2021 | CF Monterrey | - | Mazatlán FC | 1:0 |
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