| 2. Jornada | 15.03.2021 | Blooming | - | Independiente Petrolero | 2:2 |  |
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| 4. Jornada | 12.04.2021 | Bolívar | - | Independiente Petrolero | 1:0 | ||||
| 6. Jornada | 01.05.2021 | Club Aurora | - | Independiente Petrolero | 3:0 | ||||
| 8. Jornada | 10.07.2021 | Real Tomayapo | - | Independiente Petrolero | 0:2 | ||||
| 10. Jornada | 22.07.2021 | Club San José | - | Independiente Petrolero | 1:3 | ||||
| 12. Jornada | 31.07.2021 | Real Santa Cruz | - | Independiente Petrolero | 2:0 | ||||
| 18. Jornada | 13.09.2021 | The Strongest | - | Independiente Petrolero | 1:1 | ||||
| 24. Jornada | 27.10.2021 | Always Ready | - | Independiente Petrolero | 2:2 | ||||
| 26. Jornada | 21.11.2021 | Royal Pari | - | Independiente Petrolero | 3:1 | ||||
| 28. Jornada | 02.12.2021 | Real Potosí | - | Independiente Petrolero | 0:5 |
Bolivia