| 1. Jornada | 08.01.2022 | Mazatlán FC [] | - | Atlas Guadalajara [] | 0:4 | ||||
| 2. Jornada | 15.01.2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 |  |
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| 3. Jornada | 22.01.2022 | Atlas Guadalajara [] | - | CF Monterrey [] | 2:1 |  |
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| 4. Jornada | 29.01.2022 | Atlético San Luis [] | - | Atlas Guadalajara [] | 0:2 | ||||
| 6. Jornada | 12.02.2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 | ||||
| 7. Jornada | 19.02.2022 | Atlas Guadalajara [] | - | UANL Tigres [] | 5:2 | |
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| 8. Jornada | 26.02.2022 | Atlas Guadalajara [] | - | Club León [] | 4:1 | |
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| 9. Jornada | 05.03.2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 2:2 | ||||
| 10. Jornada | 12.03.2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 3:0 | |
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| 18. Jornada | 07.05.2022 | Atlas Guadalajara [] | - | Atlético San Luis [] | 2:2 |
México