| 4. Jornada | 26.02.2022 | Montevideo Wanderers | - | Defensor Sporting | 1:0 |  |
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| 5. Jornada | 12.03.2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | ||||
| 6. Jornada | 21.03.2022 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 7. Jornada | 03.04.2022 | Defensor Sporting | - | River Plate | 3:2 | ||||
| 8. Jornada | 09.04.2022 | Cerro Largo | - | Defensor Sporting | 0:0 | ||||
| 9. Jornada | 16.04.2022 | Defensor Sporting | - | Fénix | 2:1 | |
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| 10. Jornada | 26.04.2022 | Defensor Sporting | - | Cerrito | 0:0 | ||||
| 11. Jornada | 07.05.2022 | Albion | - | Defensor Sporting | 0:3 | ||||
| 12. Jornada | 14.05.2022 | Defensor Sporting | - | Nacional | 0:2 | ||||
| 13. Jornada | 22.05.2022 | Danubio | - | Defensor Sporting | 1:2 | ||||
| 14. Jornada | 29.05.2022 | Defensor Sporting | - | Deportivo Maldonado | 1:1 | ||||
| 15. Jornada | 05.06.2022 | Rentistas | - | Defensor Sporting | 1:0 | |
Uruguay