| 1. Jornada | 25.07.2021 | Lokomotiv Plovdiv | - | PFC Ludogorets Razgrad | 1:3 | ||||
| 2. Jornada | 01.08.2021 | Lokomotiv Sofia | - | Lokomotiv Plovdiv | 1:0 |  |
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| 4. Jornada | 16.08.2021 | Cherno More Varna | - | Lokomotiv Plovdiv | 0:0 | ||||
| 5. Jornada | 22.08.2021 | Lokomotiv Plovdiv | - | Slavia Sofia | 0:1 | ||||
| 6. Jornada | 28.08.2021 | Botev Vratsa | - | Lokomotiv Plovdiv | 0:0 | |
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| 7. Jornada | 12.09.2021 | Lokomotiv Plovdiv | - | Levski Sofia | 2:2 | |
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| 8. Jornada | 17.09.2021 | Tsarsko Selo Sofia | - | Lokomotiv Plovdiv | 0:2 | ||||
| 9. Jornada | 25.09.2021 | Lokomotiv Plovdiv | - | Botev Plovdiv | 1:1 | |
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| 10. Jornada | 01.10.2021 | PFC Beroe | - | Lokomotiv Plovdiv | 1:0 | ||||
| 11. Jornada | 15.10.2021 | Lokomotiv Plovdiv | - | Arda Kardzhali | 0:0 | |
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| 12. Jornada | 22.10.2021 | Lokomotiv Plovdiv | - | CSKA 1948 Sofia | 2:1 | ||||
| 13. Jornada | 31.10.2021 | CSKA Sofia | - | Lokomotiv Plovdiv | 1:3 | ||||
| 15. Jornada | 21.11.2021 | Lokomotiv Plovdiv | - | Lokomotiv Sofia | 2:1 | ||||
| 16. Jornada | 27.11.2021 | Pirin Blagoevgrad | - | Lokomotiv Plovdiv | 2:3 | ||||
| 17. Jornada | 01.12.2021 | Lokomotiv Plovdiv | - | Cherno More Varna | 1:1 |
Ucrania