| 1. Jornada | 23.07.2021 | FK Lviv | - | FK Mariupol | 1:1 | ||||
| 2. Jornada | 30.07.2021 | FK Lviv | - | Shakhtar Donetsk | 0:3 | ||||
| 4. Jornada | 15.08.2021 | FK Lviv | - | FK Oleksandriya | 1:1 | ||||
| 5. Jornada | 23.08.2021 | FK Lviv | - | Inhulets Petrove | 1:2 | ||||
| 7. Jornada | 13.09.2021 | NK Veres | - | FK Lviv | 1:0 | ||||
| 9. Jornada | 26.09.2021 | FC Mynai | - | FK Lviv | 1:2 |  |
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| 10. Jornada | 02.10.2021 | FK Lviv | - | SK Dnipro-1 | 0:1 | |
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| 11. Jornada | 16.10.2021 | FK Lviv | - | Dinamo Kiev | 1:4 | ||||
| 12. Jornada | 23.10.2021 | Chernomorets Odessa | - | FK Lviv | 1:1 | |
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| 14. Jornada | 07.11.2021 | FK Lviv | - | Desna Chernigov | 0:2 | |
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| 17. Jornada | 03.12.2021 | Shakhtar Donetsk | - | FK Lviv | 6:1 | ||||
| 18. Jornada | 11.12.2021 | FK Lviv | - | Vorskla Poltava | 1:1 |
Ucrania