| 5. Jornada | 08.08.2021 | San Diego Loyal | - | Real Monarchs SLC | 0:1 | ||||
| 5. Jornada | 15.08.2021 | San Diego Loyal | - | Tacoma Defiance | 1:2 | ||||
| 5. Jornada | 19.08.2021 | San Diego Loyal | - | Las Vegas Lights FC | 5:1 | ||||
| 5. Jornada | 22.08.2021 | San Diego Loyal | - | Orange County SC | 1:2 | ||||
| 5. Jornada | 29.08.2021 | Sacramento Republic | - | San Diego Loyal | 1:3 |  |
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| 6. Jornada | 06.09.2021 | San Diego Loyal | - | Los Angeles Galaxy II | 4:2 | ||||
| 6. Jornada | 12.09.2021 | Oakland Roots | - | San Diego Loyal | 0:0 | ||||
| 7. Jornada | 18.10.2021 | San Diego Loyal | - | New Mexico United | 1:1 | ||||
| 7. Jornada | 21.10.2021 | Orange County SC | - | San Diego Loyal | 1:0 | ||||
| 7. Jornada | 25.10.2021 | San Diego Loyal | - | Oakland Roots | 3:4 | ||||
| 7. Jornada | 31.10.2021 | Sacramento Republic | - | San Diego Loyal | 1:1 |
Estados Unidos