| 1. Jornada | 28.07.2020 | Mazatlán FC | - | Puebla FC | 1:4 | ||||
| 2. Jornada | 01.08.2020 | Puebla FC | - | Cruz Azul | 1:1 | ||||
| 3. Jornada | 09.08.2020 | Deportivo Guadalajara | - | Puebla FC | 0:1 | ||||
| 4. Jornada | 12.08.2020 | UANL Tigres | - | Puebla FC | 2:1 | ||||
| 5. Jornada | 15.08.2020 | Puebla FC | - | CF Pachuca | 0:1 | ||||
| 6. Jornada | 24.08.2020 | Club Tijuana | - | Puebla FC | 1:0 | ||||
| 7. Jornada | 29.08.2020 | Puebla FC | - | Deportivo Toluca | 4:1 | ||||
| 8. Jornada | 06.09.2020 | Pumas UNAM | - | Puebla FC | 4:1 | ||||
| 9. Jornada | 09.09.2020 | Puebla FC | - | CF América | 2:3 | ||||
| 10. Jornada | 12.09.2020 | FC Juárez | - | Puebla FC | 1:0 | ||||
| 11. Jornada | 19.09.2020 | Club Necaxa | - | Puebla FC | 0:1 |  |
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| 12. Jornada | 26.09.2020 | Puebla FC | - | Gallos Blancos | 3:3 | ||||
| 13. Jornada | 03.10.2020 | Puebla FC | - | Santos Laguna | 0:2 | ||||
| 14. Jornada | 18.10.2020 | CF Monterrey | - | Puebla FC | 3:1 | ||||
| 15. Jornada | 24.10.2020 | Puebla FC | - | Club León | 1:2 | ||||
| 16. Jornada | 01.11.2020 | Atlas Guadalajara | - | Puebla FC | 0:1 | ||||
| 17. Jornada | 07.11.2020 | Puebla FC | - | Atlético San Luis | 1:0 |  |
Colombia
México 
