| 1. Jornada | 07.08.2021 | FC Chiasso | - | FC Stade Nyonnais | 3:0 |  |
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| 2. Jornada | 18.08.2021 | FC Chiasso | - | AC Bellinzona | 2:1 | ||||
| 3. Jornada | 22.08.2021 | BSC Young Boys II | - | FC Chiasso | 0:1 | ||||
| 4. Jornada | 28.08.2021 | FC Rapperswil-Jona | - | FC Chiasso | 0:5 | ||||
| 5. Jornada | 04.09.2021 | FC Chiasso | - | FC Biel/Bienne | 0:3 | ||||
| 6. Jornada | 11.09.2021 | FC Basel 1893 II | - | FC Chiasso | 3:3 | ||||
| 8. Jornada | 25.09.2021 | Etoile Carouge FC | - | FC Chiasso | 0:3 | |
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| 7. Jornada | 29.09.2021 | FC Chiasso | - | FC Sion II | 1:2 | ||||
| 9. Jornada | 03.10.2021 | FC Chiasso | - | FC Zürich II | 1:1 | ||||
| 11. Jornada | 16.10.2021 | FC Chiasso | - | SC Brühl | 1:1 | ||||
| 12. Jornada | 23.10.2021 | SC YF/Juventus Zürich | - | FC Chiasso | 1:2 | ||||
| 13. Jornada | 31.10.2021 | FC Chiasso | - | SC Cham | 3:0 | |
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| 14. Jornada | 06.11.2021 | FC Black Stars Basel | - | FC Chiasso | 0:3 | ||||
| 15. Jornada | 14.11.2021 | FC Chiasso | - | FC Bavois | 1:1 | ||||
| 16. Jornada | 20.11.2021 | FC Stade Nyonnais | - | FC Chiasso | 1:0 | ||||
| 17. Jornada | 28.11.2021 | AC Bellinzona | - | FC Chiasso | 1:1 | ||||
| 18. Jornada | 05.12.2021 | FC Chiasso | - | BSC Young Boys II | 1:2 | |
Suiza