| 1. Jornada | 08.01.2022 | Puebla FC | - | CF América | 1:1 | ||||
| 2. Jornada | 16.01.2022 | UANL Tigres | - | Puebla FC | 0:2 |  |
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| 4. Jornada | 06.02.2022 | Gallos Blancos | - | Puebla FC | 0:2 | ||||
| 5. Jornada | 12.02.2022 | Puebla FC | - | Atlas Guadalajara | 1:1 | ||||
| 6. Jornada | 19.02.2022 | Puebla FC | - | CF Monterrey | 1:0 | ||||
| 7. Jornada | 27.02.2022 | Deportivo Guadalajara | - | Puebla FC | 2:3 | ||||
| 8. Jornada | 02.03.2022 | Puebla FC | - | FC Juárez | 1:1 | ||||
| 9. Jornada | 06.03.2022 | Cruz Azul | - | Puebla FC | 1:3 | ||||
| 10. Jornada | 14.03.2022 | Atlético San Luis | - | Puebla FC | 2:1 | ||||
| 11. Jornada | 19.03.2022 | Puebla FC | - | Santos Laguna | 2:2 | |
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| 12. Jornada | 03.04.2022 | Deportivo Toluca | - | Puebla FC | 2:1 | ||||
| 13. Jornada | 09.04.2022 | Puebla FC | - | Pumas UNAM | 2:2 | |
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| 14. Jornada | 17.04.2022 | Club León | - | Puebla FC | 0:1 |  |
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| 16. Jornada | 23.04.2022 | Puebla FC | - | Club Necaxa | 0:1 | ||||
| 17. Jornada | 30.04.2022 | Mazatlán FC | - | Puebla FC | 2:1 | |
Chile