| 1. Jornada | 13.09.2021 | Progreso | - | Villa Española | 1:1 |  |
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| 2. Jornada | 18.09.2021 | Villa Española | - | Sud América | 1:2 | |
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| 3. Jornada | 25.09.2021 | Plaza Colonia | - | Villa Española | 4:0 | ||||
| 4. Jornada | 02.10.2021 | Villa Española | - | Fénix | 1:2 | |
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| 5. Jornada | 10.10.2021 | Boston River | - | Villa Española | 1:0 | ||||
| 6. Jornada | 17.10.2021 | Villa Española | - | Montevideo Wanderers | 2:2 | ||||
| 11. Jornada | 07.11.2021 | Villa Española | - | Nacional | 1:2 | ||||
| 12. Jornada | 13.11.2021 | Cerrito | - | Villa Española | 1:0 | ||||
| 13. Jornada | 19.11.2021 | Villa Española | - | Liverpool | 0:3 |
Uruguay