| 1. Jornada | 06.02.2021 | 12 de Octubre de Itauguá | - | River Plate | 2:2 |  |
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| 2. Jornada | 09.02.2021 | River Plate | - | Guaraní | 1:4 | ||||
| 3. Jornada | 15.02.2021 | Sol de América | - | River Plate | 1:1 | |
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| 4. Jornada | 19.02.2021 | River Plate | - | Sportivo Luqueño | 1:0 | ||||
| 5. Jornada | 02.03.2021 | Libertad | - | River Plate | 2:1 | ||||
| 6. Jornada | 05.03.2021 | River Plate | - | Guaireña FC | 0:1 | ||||
| 7. Jornada | 10.03.2021 | Cerro Porteño | - | River Plate | 3:0 | ||||
| 8. Jornada | 13.03.2021 | River Plate | - | Club Nacional | 0:0 | ||||
| 9. Jornada | 22.03.2021 | Club Olimpia | - | River Plate | 5:1 | |
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| 10. Jornada | 02.04.2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | ||||
| 11. Jornada | 13.04.2021 | Guaraní | - | River Plate | 2:0 |  |
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| 12. Jornada | 18.04.2021 | River Plate | - | Sol de América | 0:2 | ||||
| 13. Jornada | 27.04.2021 | Sportivo Luqueño | - | River Plate | 2:2 | |
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| 14. Jornada | 04.05.2021 | River Plate | - | Libertad | 1:3 | ||||
| 15. Jornada | 10.05.2021 | Guaireña FC | - | River Plate | 0:0 | ||||
| 18. Jornada | 30.05.2021 | River Plate | - | Club Olimpia | 1:2 | |
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