| 1. Jornada | 24.07.2021 | FC Luzern | - | BSC Young Boys | 3:4 |  |
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| 11. Jornada | 24.10.2021 | FC Luzern | - | FC St. Gallen | 2:0 | ||||
| 12. Jornada | 31.10.2021 | FC Lausanne-Sport | - | FC Luzern | 1:1 | ||||
| 13. Jornada | 06.11.2021 | FC Luzern | - | FC Sion | 0:1 | ||||
| 15. Jornada | 28.11.2021 | FC Luzern | - | Basilea | 1:3 |  |
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| 17. Jornada | 12.12.2021 | Grasshopper Club Zürich | - | FC Luzern | 1:1 | ||||
| 18. Jornada | 18.12.2021 | FC Luzern | - | Servette FC | 0:2 | ||||
| 19. Jornada | 30.01.2022 | FC Luzern | - | Basilea | 0:3 | ||||
| 30. Jornada | 18.04.2022 | FC Luzern | - | FC St. Gallen | 3:2 | ||||
| 31. Jornada | 24.04.2022 | Basilea | - | FC Luzern | 3:0 | ||||
| 34. Jornada | 11.05.2022 | FC Sion | - | FC Luzern | 1:3 | |
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| 35. Jornada | 19.05.2022 | FC Luzern | - | BSC Young Boys | 2:2 | |
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| 36. Jornada | 22.05.2022 | FC Zürich | - | FC Luzern | 2:3 |
Suiza