| 1. Jornada | 08.08.2020 | FK Senica | - | MŠK Žilina | 0:4 | ||||
| 2. Jornada | 11.08.2020 | MŠK Žilina | - | FC Nitra | 1:2 | ||||
| 3. Jornada | 15.08.2020 | AS Trenčín | - | MŠK Žilina | 2:4 | ||||
| 4. Jornada | 22.08.2020 | FK Pohronie | - | MŠK Žilina | 2:1 | ||||
| 5. Jornada | 30.08.2020 | MŠK Žilina | - | MFK Zemplín Michalovce | 6:2 |  |
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| 6. Jornada | 12.09.2020 | ŠKF Sereď | - | MŠK Žilina | 3:2 | ||||
| 7. Jornada | 20.09.2020 | MŠK Žilina | - | Slovan Bratislava | 2:2 | ||||
| 8. Jornada | 26.09.2020 | Zlaté Moravce | - | MŠK Žilina | 4:0 | ||||
| 9. Jornada | 03.10.2020 | MŠK Žilina | - | FC DAC 1904 | 4:1 | ||||
| 10. Jornada | 18.10.2020 | MŠK Žilina | - | Spartak Trnava | 2:1 | ||||
| 11. Jornada | 24.10.2020 | MFK Ružomberok | - | MŠK Žilina | 2:1 | ||||
| 12. Jornada | 31.10.2020 | MŠK Žilina | - | FK Senica | 3:1 | ||||
| 18. Jornada | 16.12.2020 | Slovan Bratislava | - | MŠK Žilina | 3:2 | ||||
| 21. Jornada | 27.02.2021 | Spartak Trnava | - | MŠK Žilina | 2:1 | ||||
| 22. Jornada | 06.03.2021 | MŠK Žilina | - | MFK Ružomberok | 3:2 | |
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Eslovaquia