| 1. Jornada | 04.07.2022 | Atlético San Luis | - | Club León | 1:2 | ||||
| 2. Jornada | 10.07.2022 | Deportivo Guadalajara | - | Atlético San Luis | 0:1 |  |
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| 3. Jornada | 18.07.2022 | Atlético San Luis | - | CF Monterrey | 0:1 | ||||
| 4. Jornada | 23.07.2022 | Mazatlán FC | - | Atlético San Luis | 1:1 | |
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| 5. Jornada | 27.07.2022 | Atlético San Luis | - | Cruz Azul | 0:0 | ||||
| 6. Jornada | 31.07.2022 | Puebla FC | - | Atlético San Luis | 0:0 | ||||
| 16. Jornada | 04.08.2022 | FC Juárez | - | Atlético San Luis | 1:1 | ||||
| 7. Jornada | 07.08.2022 | Atlético San Luis | - | Club Necaxa | 1:2 | ||||
| 8. Jornada | 12.08.2022 | Gallos Blancos | - | Atlético San Luis | 1:1 | ||||
| 9. Jornada | 19.08.2022 | Atlético San Luis | - | Pumas UNAM | 3:2 |
México