| 1. Jornada | 09.07.2016 | Libertad | - | River Plate | 1:1 | ||||
| 4. Jornada | 25.07.2016 | River Plate | - | Club Olimpia | 0:2 | ||||
| 6. Jornada | 07.08.2016 | River Plate | - | General Caballero ZC | 1:1 | ||||
| 7. Jornada | 12.08.2016 | Sportivo Luqueño | - | River Plate | 1:0 | ||||
| 8. Jornada | 20.08.2016 | Deportivo Capiatá | - | River Plate | 0:3 | ||||
| 9. Jornada | 29.08.2016 | River Plate | - | Cerro Porteño | 2:3 | ||||
| 10. Jornada | 10.09.2016 | Sol de América | - | River Plate | 2:6 | ||||
| 12. Jornada | 24.09.2016 | River Plate | - | Libertad | 2:0 |  |
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| 16. Jornada | 29.10.2016 | River Plate | - | Club Rubio Ñu | 0:2 | ||||
| 17. Jornada | 05.11.2016 | General Caballero ZC | - | River Plate | 1:0 | ||||
| 19. Jornada | 26.11.2016 | River Plate | - | Deportivo Capiatá | 2:4 | ||||
| 20. Jornada | 02.12.2016 | Cerro Porteño | - | River Plate | 4:0 |
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