| 4. Jornada | 09.02.2016 | Libertad | - | River Plate | 3:1 | ||||
| 5. Jornada | 13.02.2016 | River Plate | - | General Caballero ZC | 0:0 | ||||
| 6. Jornada | 20.02.2016 | Club Nacional | - | River Plate | 0:0 | ||||
| 7. Jornada | 27.02.2016 | River Plate | - | Guaraní | 1:1 | ||||
| 8. Jornada | 02.03.2016 | Deportivo Capiatá | - | River Plate | 1:1 |  |
|||
| 13. Jornada | 06.04.2016 | River Plate | - | Sol de América | 1:1 | ||||
| 14. Jornada | 11.04.2016 | Sportivo Luqueño | - | River Plate | 2:0 | |
|||
| 15. Jornada | 17.04.2016 | River Plate | - | Libertad | 1:3 | ||||
| 16. Jornada | 21.04.2016 | General Caballero ZC | - | River Plate | 2:3 | ||||
| 17. Jornada | 25.04.2016 | River Plate | - | Club Nacional | 1:3 |  |
|||
| 21. Jornada | 14.05.2016 | River Plate | - | General Díaz | 1:1 | ||||
| 22. Jornada | 22.05.2016 | Club Olimpia | - | River Plate | 3:0 |
Paraguay