| 8. Jornada | 26.02.2019 | San Lorenzo | - | Cerro Porteño | 2:1 |  |
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| 9. Jornada | 04.03.2019 | Libertad | - | San Lorenzo | 2:1 | ||||
| 10. Jornada | 08.03.2019 | San Lorenzo | - | Deportivo Capiatá | 0:1 | ||||
| 11. Jornada | 18.03.2019 | General Díaz | - | San Lorenzo | 3:3 | ||||
| 12. Jornada | 24.03.2019 | River Plate | - | San Lorenzo | 2:1 | |
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| 13. Jornada | 31.03.2019 | San Lorenzo | - | Club Olimpia | 1:4 | ||||
| 14. Jornada | 05.04.2019 | Club Nacional | - | San Lorenzo | 3:1 | ||||
| 15. Jornada | 09.04.2019 | Guaraní | - | San Lorenzo | 4:1 | ||||
| 16. Jornada | 13.04.2019 | San Lorenzo | - | Sportivo Luqueño | 0:3 |
Paraguay