| 3. Jornada | 20.02.2022 | General Caballero DJLM | - | Tacuary | 2:0 | ||||
| 4. Jornada | 28.02.2022 | Tacuary | - | Libertad | 0:1 | ||||
| 8. Jornada | 04.04.2022 | Guaraní | - | Tacuary | 1:2 |  |
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| 11. Jornada | 22.04.2022 | Tacuary | - | Cerro Porteño | 2:0 | ||||
| 12. Jornada | 26.04.2022 | Tacuary | - | Resistencia SC | 3:1 | ||||
| 13. Jornada | 30.04.2022 | 12 de Octubre de Itauguá | - | Tacuary | 2:0 | ||||
| 14. Jornada | 07.05.2022 | Tacuary | - | General Caballero DJLM | 0:0 | ||||
| 15. Jornada | 11.05.2022 | Libertad | - | Tacuary | 3:0 | ||||
| 17. Jornada | 20.05.2022 | Tacuary | - | Sportivo Ameliano | 1:0 | ||||
| 19. Jornada | 20.06.2022 | Tacuary | - | Guaraní | 0:2 | ||||
| 20. Jornada | 24.06.2022 | Guaireña FC | - | Tacuary | 0:0 | ||||
| 21. Jornada | 28.06.2022 | Tacuary | - | Sol de América | 2:2 | ||||
| 22. Jornada | 02.07.2022 | Cerro Porteño | - | Tacuary | 1:0 |
Paraguay