| 5. Jornada | 04.02.2022 | Atlético San Luis [Sub 16] | - | Santos Laguna [Sub 16] | 2:1 | ||||
| 12. Jornada | 26.03.2022 | Santos Laguna [Sub 16] | - | Mazatlán FC [Sub 16] | 3:1 | ||||
| 17. Jornada | 30.04.2022 | Deportivo Guadalajara [Sub 16] | - | Santos Laguna [Sub 16] | 3:0 | ||||
| 18. Jornada | 07.05.2022 | Santos Laguna [Sub 16] | - | Club León [Sub 16] | 2:1 |
México