| 8. Jornada | 14.03.2021 | Guaraní | - | Guaireña FC | 0:3 | ||||
| 14. Jornada | 02.05.2021 | Guaraní | - | Sol de América | 2:0 | ||||
| 15. Jornada | 08.05.2021 | Sportivo Luqueño | - | Guaraní | 1:2 | ||||
| 17. Jornada | 22.05.2021 | Guaireña FC | - | Guaraní | 0:0 | ||||
| 18. Jornada | 29.05.2021 | Guaraní | - | Cerro Porteño | 2:0 |  |
Paraguay