| 5. Jornada | 25.09.2021 | Gudja United | - | Valletta FC | 2:0 | ||||
| 6. Jornada | 17.10.2021 | Valletta FC | - | Sirens FC | 3:1 | ||||
| 7. Jornada | 24.10.2021 | Hibernians FC | - | Valletta FC | 1:1 | ||||
| 9. Jornada | 20.11.2021 | Sliema Wanderers | - | Valletta FC | 0:3 | ||||
| 10. Jornada | 27.11.2021 | Valletta FC | - | Mosta FC | 3:1 | ||||
| 11. Jornada | 04.12.2021 | Valletta FC | - | Birkirkara FC | 0:0 | ||||
| 12. Jornada | 13.12.2021 | Valletta FC | - | Hamrun Spartans | 0:1 | ||||
| 14. Jornada | 17.01.2022 | Valletta FC | - | Floriana FC | 0:2 | ||||
| 15. Jornada | 23.01.2022 | Gżira United | - | Valletta FC | 1:1 | ||||
| 17. Jornada | 06.02.2022 | Sirens FC | - | Valletta FC | 2:1 | ||||
| 18. Jornada | 12.02.2022 | Valletta FC | - | Hibernians FC | 1:4 | ||||
| 20. Jornada | 26.02.2022 | Valletta FC | - | Sliema Wanderers | 1:0 | ||||
| 21. Jornada | 05.03.2022 | Mosta FC | - | Valletta FC | 2:2 | ||||
| 22. Jornada | 12.03.2022 | Birkirkara FC | - | Valletta FC | 1:1 |  |
Feliz Cumpleaños! 
Malta