| 1. Jornada | 27.01.2023 | Libertad | - | Guaraní | 1:0 | ||||
| 2. Jornada | 04.02.2023 | Guaraní | - | Sportivo Ameliano | 2:2 | ||||
| 3. Jornada | 12.02.2023 | Cerro Porteño | - | Guaraní | 1:1 |  |
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| 4. Jornada | 17.02.2023 | Resistencia SC | - | Guaraní | 0:4 | ||||
| 5. Jornada | 25.02.2023 | Guaraní | - | Sportivo Luqueño | 3:1 | ||||
| 6. Jornada | 04.03.2023 | Club Nacional | - | Guaraní | 0:2 | ||||
| 7. Jornada | 14.03.2023 | Guaraní | - | Tacuary | 1:0 | |
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| 8. Jornada | 20.03.2023 | Sportivo Trinidense | - | Guaraní | 1:1 | ||||
| 9. Jornada | 24.03.2023 | Guaraní | - | Guaireña FC | 1:1 | |
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| 10. Jornada | 01.04.2023 | Club Olimpia | - | Guaraní | 0:1 | ||||
| 11. Jornada | 11.04.2023 | Guaraní | - | General Caballero DJLM | 3:1 | |
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| 13. Jornada | 17.04.2023 | Sportivo Ameliano | - | Guaraní | 1:1 | ||||
| 14. Jornada | 25.04.2023 | Guaraní | - | Cerro Porteño | 0:3 | |
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| 16. Jornada | 06.05.2023 | Sportivo Luqueño | - | Guaraní | 3:0 | |
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| 17. Jornada | 14.05.2023 | Guaraní | - | Club Nacional | 2:2 | ||||
| 18. Jornada | 18.05.2023 | Tacuary | - | Guaraní | 1:3 | |
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| 20. Jornada | 29.05.2023 | Guaireña FC | - | Guaraní | 2:2 | |
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| 21. Jornada | 03.06.2023 | Guaraní | - | Club Olimpia | 1:2 |
Argentina