| 2. Jornada | 19.03.2022 | Toronto FC | - | D.C. United | 2:1 |  |
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| 3. Jornada | 03.04.2022 | D.C. United | - | Atlanta United FC | 0:1 |  |
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| 3. Jornada | 17.04.2022 | D.C. United | - | Austin FC | 2:3 | ||||
| 3. Jornada | 24.04.2022 | D.C. United | - | New England Revolution | 3:2 | ||||
| 4. Jornada | 01.05.2022 | Columbus Crew | - | D.C. United | 3:0 | ||||
| 4. Jornada | 08.05.2022 | D.C. United | - | Houston Dynamo | 2:0 | |
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| 4. Jornada | 15.05.2022 | Inter Miami CF | - | D.C. United | 2:2 | |
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| 4. Jornada | 19.05.2022 | D.C. United | - | New York City FC | 0:2 | ||||
| 4. Jornada | 29.05.2022 | New York RB | - | D.C. United | 4:1 | ||||
| 5. Jornada | 19.06.2022 | Chicago Fire | - | D.C. United | 1:0 | ||||
| 5. Jornada | 25.06.2022 | D.C. United | - | Nashville SC | 1:3 | ||||
| 6. Jornada | 17.07.2022 | Minnesota United FC | - | D.C. United | 2:0 | ||||
| 7. Jornada | 04.08.2022 | Charlotte FC | - | D.C. United | 3:0 | |
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| 7. Jornada | 07.08.2022 | D.C. United | - | New York RB | 0:0 | ||||
| 8. Jornada | 01.09.2022 | New York City FC | - | D.C. United | 1:2 | ||||
| 8. Jornada | 05.09.2022 | D.C. United | - | Colorado Rapids | 0:0 | ||||
| 8. Jornada | 11.09.2022 | Real Salt Lake | - | D.C. United | 0:0 | ||||
| 8. Jornada | 18.09.2022 | D.C. United | - | Inter Miami CF | 2:3 |
Estados Unidos