| 6. Jornada | 12.02.2022 | UANL Tigres [Sub 16] | - | CF Monterrey [Sub 16] | 1:0 | ||||
| 7. Jornada | 19.02.2022 | Atlas Guadalajara [Sub 16] | - | UANL Tigres [Sub 16] | 1:1 | ||||
| 8. Jornada | 26.02.2022 | UANL Tigres [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 1:4 |  |
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| 9. Jornada | 05.03.2022 | Atlético San Luis [Sub 16] | - | UANL Tigres [Sub 16] | 1:1 | ||||
| 10. Jornada | 12.03.2022 | UANL Tigres [Sub 16] | - | Club León [Sub 16] | 2:1 | ||||
| 11. Jornada | 19.03.2022 | UANL Tigres [Sub 16] | - | Mazatlán FC [Sub 16] | 0:0 |
México