| 1. Jornada | 18.07.2021 | Club Olimpia | - | River Plate | 1:3 |  |
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| 5. Jornada | 15.08.2021 | Club Olimpia | - | Cerro Porteño | 0:3 | |
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| 6. Jornada | 23.08.2021 | Sportivo Luqueño | - | Club Olimpia | 2:0 | ||||
| 7. Jornada | 29.08.2021 | Club Olimpia | - | Sol de América | 0:1 | ||||
| 8. Jornada | 13.09.2021 | Libertad | - | Club Olimpia | 0:3 | ||||
| 9. Jornada | 21.09.2021 | Club Olimpia | - | Club Nacional | 1:2 | ||||
| 10. Jornada | 27.09.2021 | River Plate | - | Club Olimpia | 1:2 | |
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| 11. Jornada | 02.10.2021 | Club Olimpia | - | 12 de Octubre de Itauguá | 1:2 | ||||
| 12. Jornada | 18.10.2021 | Guaireña FC | - | Club Olimpia | 0:2 | ||||
| 13. Jornada | 24.10.2021 | Club Olimpia | - | Guaraní | 1:3 | ||||
| 14. Jornada | 31.10.2021 | Cerro Porteño | - | Club Olimpia | 1:0 | ||||
| 15. Jornada | 08.11.2021 | Club Olimpia | - | Sportivo Luqueño | 4:0 | ||||
| 16. Jornada | 21.11.2021 | Sol de América | - | Club Olimpia | 1:0 | ||||
| 17. Jornada | 26.11.2021 | Club Olimpia | - | Libertad | 2:3 | |
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| 18. Jornada | 05.12.2021 | Club Nacional | - | Club Olimpia | 1:3 |
Colombia