| 9. Jornada | 13.09.2021 | FK Legion Dynamo Makhachkala | - | FK Druzhba | 1:2 | ||||
| 10. Jornada | 18.09.2021 | FK Druzhba | - | FK Mashuk KMV | 1:1 | ||||
| 11. Jornada | 26.09.2021 | Spartak Nalchik | - | FK Druzhba | 0:0 | ||||
| 12. Jornada | 03.10.2021 | FK Druzhba | - | FK Chayka | 0:2 | ||||
| 13. Jornada | 10.10.2021 | Anzhi Makhachkala | - | FK Druzhba | 0:0 | ||||
| 15. Jornada | 23.10.2021 | FK Druzhba | - | Alania-2 Vladikavkaz | 1:1 |  |
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| 17. Jornada | 06.11.2021 | FK Druzhba | - | Forte Taganrog | 1:2 | ||||
| 18. Jornada | 13.11.2021 | Rotor-2 Volgograd | - | FK Druzhba | 0:0 | ||||
| 19. Jornada | 19.11.2021 | FK Druzhba | - | FK Tuapse | 1:0 | |
Rusia