| 5. Jornada | 18.07.2010 | Columbus Crew | - | New York RB | 2:0 | ||||
| 5. Jornada | 25.07.2010 | Columbus Crew | - | Houston Dynamo | 3:0 | ||||
| 6. Jornada | 01.08.2010 | CD Chivas | - | Columbus Crew | 3:1 |  |
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| 6. Jornada | 06.08.2010 | Philadelphia Union | - | Columbus Crew | 1:2 | ||||
| 6. Jornada | 15.08.2010 | Real Salt Lake | - | Columbus Crew | 2:0 | ||||
| 6. Jornada | 22.08.2010 | Columbus Crew | - | Colorado Rapids | 3:1 | ||||
| 6. Jornada | 28.08.2010 | Columbus Crew | - | FC Dallas | 0:0 | ||||
| 7. Jornada | 05.09.2010 | D.C. United | - | Columbus Crew | 0:1 | |
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| 7. Jornada | 12.09.2010 | Los Angeles Galaxy | - | Columbus Crew | 3:1 | ||||
| 7. Jornada | 26.09.2010 | New England Revolution | - | Columbus Crew | 2:2 | |
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| 8. Jornada | 03.10.2010 | Columbus Crew | - | San Jose Earthquakes | 0:0 | ||||
| 8. Jornada | 24.10.2010 | Columbus Crew | - | Philadelphia Union | 3:1 |
Jamaica